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Adding to the Blank Slate: How Amnesiacs Learn to Learn

Harieshwar Vetri

One of our most impressive cognitive abilities is learning and remembering new things. Humans are thought to be the only beings capable of scientific learning, the ability to relate events that are separated by an interval of 60 seconds or more (Davis, 1986). If we were to lose this ability, would we lose a part of who we were? Almost certainly. Amnesia causes people to lose their ability to learn and retain new information while also affecting their memory to varying degrees (Amnesia - Symptoms and Causes, 2022).

Amnesia from trauma is often temporary, in time the individuals will be able to recover from this and regain all of their cognitive functions (Amnesia - Symptoms and Causes, 2022). Nonetheless, they will have to deal with this loss of function for that period and there are, unfortunately, no treatments or interventions that can speed up this process. Fortunately, there is evidence that shows that there is some retention, or at the very least recovery, of these facilities very early in the recovery of the individual.

Various studies with patients suffering from all kinds of amnesia have shown that amnesiac patients can learn and become proficient in tasks in the short and long term. Take, for example, the study by Nissen et al. (1989) involving the preservation of learning in individuals suffering from Korsakoff’s syndrome. They were able to realise and remember, albeit unconsciously, a series of letters that were presented to them repeatedly. This information even remained present with them after a substantial period.

            Squire and Frambach (1990) conducted another study involving two cognitive tasks both of which were related to keeping some sort of variable at a certain level and were evaluated similarly allowing for learning to occur. The participants were not told how the variable is calculated at each step of the task and had to discern it themselves. The amnesiac cohort consisted of individuals who had developed the condition through various conditions such as anoxia and Korsakoff’s syndrome. Once again, the amnesiac cohort displayed some characteristics of learning though there seemed to be no evidence of practice when the task was carried out again a month later due to a lack of declarative knowledge- the ability to recollect facts and information.

Another interesting study was conducted by Winter (2002). The amnesiac patient, referred to as M.S., in this study had developed the condition due to anoxia which had caused damage to the bilateral hippocampus. They were introduced to the game of Tetris and taught the instructions and goals of the game. They were then allowed to play and practice on their own time and every week their scores were taken as part of a trial. When compared to a control group of 13 healthy individuals M.S. was able to outperform the control group in week 2 and caught up to their level of play by week 11, though the control group stopped giving measurements in week 4. This discrepancy was attributed in part to M.S.’s slower reaction speed but it can also be related to a lack of declarative knowledge causing him to have to effectively relearn the game every session. Curiously, however, after the study was complete, M.S. retained his access to the game and in time the experimenters reported that he had “learned” the game’s mechanics and had far exceeded both his own and the control group’s previous scores.

This particular study is interesting because you can see evidence that some form of learning and practice did in fact take place in patient M.S.’s case, though it took him an undisclosed considerable amount of time to do so. This result relates to a study once again involving amnesia and Tetris. Stickgold et al. (2000) were conducting a study to document a reported effect where people who spent large periods of time on a single activity would see images relating to these activities as they fell asleep. The study involved 27 participants who were asked to play 7 hours of Tetris over 3 days. 5 of the participants were anterograde amnesiacs with bilateral medial temporal damage, meaning they were unable to learn or even remember playing the game. Nonetheless, 3 of them reported the very same imagery of Tetris blocks dropping at sleep onset. This effect would go on to take the game’s name and be referred to as the Tetris effect and spearhead further study into game transfer phenomena.

It must be noted that in the last 3 studies all of the learning occurred with the amnesiac’s declarative knowledge being impaired or even inaccessible. And yet there is clear evidence of the participants displaying the ability to learn and retain information, even if the individual themselves cannot consciously remember. Stickgold et al. (2000) reason that there is some form of implicit memory playing a role here.

While our memory and ability to retain knowledge are often what makes us who our brains are capable of repairing themselves from what would be far more debilitating injuries. Humans seem to have an inherent curiosity and thirst for knowledge and it would seem not even damaging or wholly removing their ability to store what they have learnt will keep us from seeking and learning new things.


References

Amnesia - Symptoms and causes. (2022, November 18). Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/amnesia/symptoms-causes/syc-20353360

Davis, D. D. (1986). The uniqueness of human learning. Medical Hypotheses, 21(2), 153–164. https://doi.org/10.1016/0306-9877(86)90005-8

Nissen, M. J., Willingham, D., & Hartman, M. (1989). Explicit and implicit remembering: When is learning preserved in amnesia? Neuropsychologia, 27(3), 341–352. https://doi.org/10.1016/0028-3932(89)90023-7

Squire, L. R., & Frambach, M. (1990). Cognitive skill learning in amnesia. Psychobiology, 18(1), 109–117. https://doi.org/10.3758/bf03327224

Stickgold, R., Malia, A., Maguire, D., Roddenberry, D., & O’Connor, M. (2000). Replaying the Game: Hypnagogic Images in Normals and Amnesics. Science, 290(5490), 350–353. https://doi.org/10.1126/science.290.5490.350

Winter, W. E. (2002). Acquisition of Expertise on a Difficult Perceptual-Motor Task by an Amnesic Patient. Perceptual and Motor Skills, 94(1), 59–67. https://doi.org/10.2466/pms.2002.94.1.59

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